Modified Matter Class 6 Slides: Biotech and Beyond - Health and Medical

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1628 Harvey Circulation: 1789 Lavoisier Respiration, Oxidation, Chemistry; 1859 Darwin Evolution; 1865 Pasteur Vaccination, Fermentation

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1888Waldyer chromosomes; 1894 Felix Hoffman Bayer Aspirin

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1905 Paul Ehrlich hematology, immunology; 1905 Robert Koch bacteriology, TB; 1921 Banting Insulin; 1928 Fleming Penicillin

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1900-2000 Malaria and DDT; 1903 William Gorgas Panama Canal Sanitation; 1950's DDT neighborhood spray; 1962 Rachel Carson Silent Spring

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1951 Carl Djerassi Syntex, oral contraceptive, 2002 with Nobel Pfizer Viagra; 1952 Salk polio, 1957 Sabin; 1953 Crick Watson DNA double helix

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1970+ Alza drug delivery systems; 1973 Herb Boyer, Stanley Cohen recombinant DNA; Genetic engineering; 1976 Bob Swanson, Boyer Genentech

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1980-2014 $350 billion biotech funding, 2014 $105B+$350B M&A; 1982 Genentech rDNA insulin; Large biotech companies; Biotech funding by sector

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Wikipedia highlights of biologics and recombinant DNA types and trade name examples and characteristics

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1981 AIDS/HIV outbreak; 1996 David Ho leads cocktail therapy approach; 1996 Dolly cloned Wilmut Roslin in lab, dies 2003

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2000 Venter, NIH decode human genome; 2005-10 Drugs & Biologics FDA approved; 2009-12 biotech finance by sector; 2011 ACA cost forecasts

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2013 Biotech health opportunities and therapeutic areas; 2004 California Institute for Regenerative Medicine (CRIM) $3 billion, 10 years

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Selected Highlights and Background Stem Cells and Regenerative Medicine; 2014 ten CRIM trials to start, products years away

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2014 Gilead hepatitis C drug at $86,000 or $1000+/pill, 2015 AbbVie hepatitis C lowers price; 2015 Novartis rapamycin anti-aging potential

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2015 Graphic highlights of rapamycin effect on cells and anti-aging potential; Steve Brill extends Time medical cost analyses into book